A new mutation (db 3J) at the diabetes locus in strain 129/J mice
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چکیده
منابع مشابه
Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes
Purpose. To describe both the functional and pathological alternations in neurosensory retina in a murine model of spontaneous type 2 diabetes (db/db mouse). Methods. db/db (BKS/DB-/-) mice and heterozygous littermates (as control group) at various ages (12, 16, 20, 24, and 28 weeks) were inspected with pattern electroretinogram (PERG), fundus fluorescein angiography (FFA), and optical coherenc...
متن کاملSpontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice.
Five allelic mutants of the diabetes (db) gene have been previously described in mice and rats causing obesity, infertility, and varying degrees of diabetes. We have identified a new, spontaneous mutation resulting in obesity and diabetes in a colony of CD-1 outbred mice, Mus musculus domesticus. Genetic complementation studies indicated that the new mutation was an allele of the diabetes locus...
متن کاملEvidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice
OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain. db/db mice also produce this alternatively spliced transcript, but with a 106 nt insertion that prematurely terminates the intracellular domain. We further identified ...
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The mitochondrial outer membrane protein mitoNEET is a binding protein of the insulin sensitizer pioglitazone (5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione) and is considered a novel target for the treatment of type II diabetes. Several small-molecule compounds have been identified as mitoNEET ligands using structure-based design or virtual docking studies. How...
متن کاملCardiac Muscle Protein Catabolism in db / db Obese Mice , a Type II Diabetes Mellitus Model
Muscle wasting (skeletal and cardiac) is associated with increasing morbidity and mortality. Muscle wasting is primarily the result of increased proteolysis within muscle that leads to excessive degradation of structural proteins such as actin. Accelerated muscle protein degradation is associated with insulin resistance. Muscle protein metabolism in cardiac muscle under conditions of insulin re...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1980
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00258314